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In patients with diabetes, GLP-1 RAs have been linked to an increased risk of age-related macular degeneration, although the overall risk is still low[38]

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The results are particularly compelling (even in an observational cohort) given the large, elderly, high-risk population with long-standing diabetes and substantial cardiovascular burdenprecisely the patients who are often excluded from randomized trials and in whom real-world guidance is needed

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