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Between 2026 and 2027, several new medications are expected to reach the marketincluding oral GLP-1 drugs, dual-hormone therapies, and even triple-hormone agents designed to target multiple metabolic pathways at onc
The hepatic TGF-/Smad signaling pathway was downregulated by SEMA treatment, while sirtuin 1 (SIRT1) content and phosphorylated AMP-activated protein kinase (p-AMPK) expression were upregulated
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This study aimed to investigate whether Vutiglabridin, a novel oral small-molecule anti-obesity drug, complements GLP-1 RAs to enhance therapeutic efficacy by selectively reducing fat mass and achieving normal body composition
