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Inhibition of DPP-IV elevates endogenous GLP concentrations, but DPP-IV also independently modulates inflammatory mediators, including stromal cell-derived factor 1 (SDF-1) and regulated upon activation, normal T cell expressed and presumably secreted (RANTES) (7981)

The Mechanism: The "Gatekeepers" of the Liver The study identifies a specific hero in this process: Liver Sinusoidal Endothelial Cells (LSECs)

With at least one weight-related condition (high blood pressure, high cholesterol, type 2 diabetes)

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GLP-1 receptor agonists compensate for the reduction of GLP-1 levels and secretion in diabetic patients, giving an excellent answer in improving cognition and protecting nerves