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Description
Soluble fiber from sources like oats, legumes, vegetables, and fruits slows gastric emptying and allows nutrients to reach distal L-cells more effectively
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Moreover, the combination of glucagon with GLP-1 actions could improve WL while protecting against the risk of hyperglycaemia [64]

However, it has also been reported that although deletion of hepatocyte Dpp4 expression abolished the obesity-induced rise in circulating DPP-4 and was associated with reduced levels of proinflammatory cytokines in hepatocytes and adipose tissue, levels of circulating soluble DPP-4 per se did not correlate with tissue or systemic inflammation (82)

These findings challenge the prior notion that GIP might be obesogenic and instead suggest that pharmacological activation of GIPR could offer therapeutic benefits for weight reduction
