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Some cases need medication support or dose review

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The subjects who, at that time, switched from semaglutide 2.4mg to placebo had regained half of that weight after 48 weeks, whereas those who continued on active treatment achieved an additional weight loss of around 8% in the same time period

All GLP-1 medications follow dose-escalation protocols over 416 weeks to minimise gastrointestinal side effects such as nausea and vomiting
In the SURMOUNT-5 trial, mean weight change at 72 weeks was greater with tirzepatide