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The introduction of GLP-1s for weight loss has been a dysfunctional mess, thanks to pharmaceutical companies, insurance plans, pharmacy chains, and the federal government.

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Earlier this year, Blue Cross Blue Shield said five GLP-1 drugs now account for nearly 20% of its pharmacy spend.

It results from the metabolic consequences due to a lack of insulin secretion or impaired insulin activity in diabetes leading to dysregulated pathophysiologic pathways resulting in excessive ketone body formation

Clinicians should maintain heightened awareness for aspiration risk in perioperative settings
