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J Res Med Sci

Nausea was often reported during dose escalation, with 1017% 6 of participants discontinuing treatment across dose cohorts due to GI symptoms

These drugs are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. Other potential risks include: Acute pancreatitis Gallbladder disease (cholelithiasis, cholecystitis) Acute kidney injury Hypersensitivity reactions Patients should be monitored for persistent abdominal pain, changes in renal function, and other signs that may require discontinuation or additional workup

Kumar, R