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These grave dangers influence therapy decisions and might cause others to halt or adjust drugs

While keeping the foot of your extended leg flat on the floor, slowly lean forward and hold this stretch for 15 to 30 seconds

doi:10.1067/mcp.2002.121236

Persistent or concerning reactions: Whilst most injection site reactions are benign, persistent redness lasting beyond 72 hours, increasing pain, warmth, or swelling may indicate infection or an inflammatory response requiring medical assessment

This includes proteinuria ( 300 mg/24hr urine collection, protein/creatinine ratio of 3 mg/dL, or dipstick reading of 2+ protein if other methods are not available), thrombocytopenia ( 1.1 mg/dL), elevated liver enzymes (at least 2x upper limit of normal), pulmonary edema, or neurological symptoms (e.g., new onset headache not responding to medications or visual disturbances not attributable to another diagnosis)