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Lawsuits have been filed by people who had to be hospitalized due to extreme nausea, vomiting, abdominal pain, and other symptoms of stomach paralysis

In vivo and in vitro studies revealed that the programming of low Serpina3c expression was associated with reduced H3K27ac levels in the gene promoter region of Serpina3c caused by the activation of GR-HDAC3 signaling by the active metabolite prednisolone

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