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All four medications can cause gastrointestinal side effects, but when they occur and how severe they are can vary from one medication to another

The ~15% weight loss observed with semaglutide approaches the 2030% weight loss achieved through bariatric surgery

Qiu calls Lilly the 800-pound gorilla of the weight-loss industry

Additionally, metformin may influence lipid metabolism, smooth muscle contractions of the vascular system, hypercoagulation, platelet hyperactivity, calcium handling within cardiomyocytes and endothelial cell function [34]

However, potential adverse mental health effects have also been reported and require vigilance: Nausea and gastrointestinal symptoms , common side effects of GLP-1 medications, may increase anxiety in susceptible individuals Rapid weight loss can occasionally trigger psychological distress or exacerbate eating disorder behaviours Mood changes , including low mood, have been reported in post-marketing surveillance, though causality remains uncertain Some patients report feeling emotionally flat or detached , though this is anecdotal and not well characterised in clinical trials The Summary of Product Characteristics (SmPC) for GLP-1 receptor agonists used for weight management (such as Saxenda and Wegovy) includes specific warnings about monitoring for mood disorders and suicidal thoughts