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CLINICAL EVIDENCE OF THE USE OF GLP-1RAs IN BAD TREATMENT Two patients experiencing complete remission of BAD symptoms after initiating liraglutide treatment for type 2 diabetes and obesity, respectively (15), inspired us to compare the effect of liraglutide and the current standard-of-care treatment of BAD, the bile acid sequestrant colesevelam, in patients with idiopathic or postcholecystectomy BAD in a 6-week double-dummy, double-blind RCT (21)

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These effects could be attributed to treatment with liraglutide and not to weight loss, since they were not observed in the group of animals that lost weight without receiving the GLP-1RA [40]

Graphical abstract Similar content being viewed by others Introduction Tirzepatide (LY3298176) is the first peptide dual agonist for type 2 diabetes mellitus (T2DM), which targets both GIPR and GLP1R