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Follow-on versions of liraglutide and semaglutide, and possibly other polypeptides, should be clinically evaluated for efficacy and safety.

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A review by Frank Duca and graduate students Hallie Wachsmuth and Savanna Weninger at the University of Arizona, Tucson, USA, reveals a more complicated picture, with many different interacting neural and hormonal signals, with increasing evidence for the vital role played by the microbes in the gastrointestinal tract

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