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Data from the SURMOUNT trials showed that participants losing significant weight on tirzepatide experienced approximately 33-39% of total weight loss from lean body mass

If tirzepatide reduces intracranial pressure through direct receptor activation, independent of weight loss, it could lower the migraine threshold for a broad range of people

Most GLP-1 medications do not significantly affect the blood levels of standard oral contraceptive pills

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Data processing Untargeted metabolomic and lipidomic data processing The MS data underwent a series of pretreatment steps, such as peak picking, peak grouping, and retention time correction, via XCMS software