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6 Pathogenic signaling pathways 6.1 The PI3K/Akt signaling pathway The phosphoinositide-3 kinase/protein kinase B (PI3K/Akt) signaling pathway plays an essential role in cell survival and glucose homeostasis

[DOI] [PMC free article] [PubMed] [Google Scholar] 773.Lockie S.H., Heppner K.M., Chaudhary N., Chabenne J.R., Morgan D.A., Veyrat-Durebex C

Another way to approach this outcome would be to identify agonists that act on the GLP-1 receptor to produce the same pharmacological outcome

Meier JJ, Nauck MA, Kranz D, Holst JJ, Deacon CF, Gaeckler D, Schmidt WE, and Gallwitz B

This suggests a potential role for phentermine as a maintenance or bridge therapy after GLP-1 discontinuation, though the evidence remains preliminary