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16:0) covalently attached to the side chain amine of Lys10 in peptide 20 through a -carboxylate spacer and the Glu-2OEG linker, and C18 fatty diacid moiety that was acylated on Lys20 in tirzepatide were modeled with the CHARMM CGenFF small-molecule force field 66 , program version 1.0.0

Nonaka T, Sekino Y, Iida H, Yamada E, Ohkubo H, Sakai E, et al

Transgenic technologies have enabled isolation of primary L cell populations suitable for secretion and electrophysiological analyses (91), and stem cellderived gut organoids, including those of human origin, herald considerable potential for generation of diverse enteroendocrine cell populations from different sites along the gastrointestinal tract (92)