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Upon endocytosis by the endothelial cells, albumin binds to the Fc receptor (FcRn) during endosomal acidification, which sorts the intracellular trafficking of the albumin away from degradative lysosomes and back to the plasma membrane where it can once again reenter the general circulation

While uncomfortable, thirst rarely prevents patients from continuing treatment, as symptoms typically improve and can be effectively managed

This steadier drug level also means that GI side effects, when they occur, tend to be milder with sublingual dosing

A systematic review presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, now offers some of the most comprehensive evidence to date and the answer is not what many had feared
