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Both receptors exist in brain regions that regulate appetite, and their combined activation produces stronger appetite suppression than targeting either receptor alone

In a post-hoc analysis of the published SURPASS trials, the change in systolic blood pressure was greater for tirzepatide versus the comparators of the trials (tirzepatide 5 mg: -5.1 to -1.3 mmHg, tirzepatide 10 mg: -6.5 to -1.7 mmHg, tirzepatide 15 mg: -11.5 to -3.1 mmHg) [65]

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Nanotechnology in the treatment of inflammatory bowel diseases