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Description
GLP-1R activation exerted antifibrotic effects by blocking the interaction between the NLPR3 inflammasome and PFKFB3-driven glycolysis, leading to the inhibition of lactate production and subsequent histone lactylation, and thereby decreasing profibrotic gene expression in fibroblasts under inflammatory stress

All incretin receptors are class B1 G protein-coupled receptors (GPCRs), coupling to the G s type of heterotrimeric G proteins which activates adenylyl cyclase (AC) to produce cyclic adenosine monophosphate (cAMP)

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