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For instance, exendin-4 has been shown to ameliorate the high glucose-induced fibronectin (FN) and type I collagen (Col1) expression in tubular epithelial cells by inhibiting the secretion of miR-192, an microRNA (miRNA) that is regulated by p53 and plays a role in renal fibrosis (Li et al., 2018)

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Citing a limitation of the study, scientists said the study cohort was restricted to privately insured US individuals, which may limit the generalisability of the findings to other populations

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