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These results suggest that exendin-4-induced suppression may be mediated by a distinct G s /cAMP-PKA/IP 3 /Ca 2+ /CaM/CaMKII signaling pathway, following the activation of GLP-1Rs

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Long-term application of GLP-1RAs may also elevate the release of endogenous GLP-2, which is a cell-specific growth hormone regulating the growth of the small intestine, colonic villi and crypts, increasing the length and weight of the small intestine, and reducing antral motility