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GLP-1 (semaglutide or tirzepatide) Therapy in Older Adults: Balancing Benefit & Risk Beyond Age 65 Joshua Silva, MD Dec 12, 2025 4 min read Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Last clinically updated: December 2025 Many discussions about GLP-1 medications in older adults come from friends, family, or acquaintances , as well as online forums, news stories, and social media posts

Group, Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study, Diabetes care, 35 (2012) 252258