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Several of the medications showed that patients with a history of cardiac disease or risk factors for cardiovascular disease had lower risks of heart attacks, strokes, and myocardial infarctions when taking these agents compared to patients taking standard of care regardless of A1C lowering [3537]

However, the association between semaglutide level and TBI remains unclear

Suboptimal dosing : Patients may be on a dose intended for diabetes management (0.5-1.0 mg weekly) rather than the higher dose approved for weight loss (2.4 mg weekly)

Its the combination of these two mechanisms that likely produces the noticeable effect seen in studies

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