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Hanyang University Professor Park Jung-hwan, who leads the Korean Society for the Study of Obesitys policy committee, called it unrealistic to imagine a lifelong drug market without answers on safety, cost and what happens after patients stop

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Figure 4 Considering that chronic beta-cell GLP-1R signaling activates cAMP-responsive element binding (CREB) and epidermal growth factor receptor (EGFR) pathways that induce pro-survival and anti-apoptotic responses (9294), in addition to the acute potentiation of GSIS, the activation of alpha-cell GLP-1 production may also serve to promote the survival and proliferation of the remaining beta-cells ( Figure 4 )