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In response to LPS, the increase in GLP-1 is dose dependent, and GLP-1 levels remain elevated for 8-h (111)

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Metformin As described above, meta-analyses of trials using metformin in adults have shown reductions in A1C, weight, and insulin dose without increased risks for hypoglycemia or ketoacidosis but with higher risk for gastrointestinal side effects

It may also be affected by dehydration, reduced food intake, low fiber intake, other medications, or underlying health conditions