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GLP-1R activation further reduces endoplasmic reticular (ER) stress in cells, preserving cellular function despite the cellular stresses induced by increased insulin biosynthesis [30] (Figure 1)

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Dual and triple agonist therapies currently in development may expand the number of future pharmacotherapy options

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Regulatory and Policy Horizons Regulators have recognized the PA burden as a priority, and 20252026 has delivered landmark reforms that move beyond voluntary pledges to binding requirements

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These findings suggested that PF augmented the expression levels of EMT biomarkers, which were markedly suppressed by dulaglutide treatment

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SK: Conceptualization, Methodology, Software, Formal Analysis, Visualization, Investigation, Writing original draft, Writing review and editing

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