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GLP-1R activation further reduces endoplasmic reticular (ER) stress in cells, preserving cellular function despite the cellular stresses induced by increased insulin biosynthesis [30] (Figure 1)
Dual and triple agonist therapies currently in development may expand the number of future pharmacotherapy options

Regulatory and Policy Horizons Regulators have recognized the PA burden as a priority, and 20252026 has delivered landmark reforms that move beyond voluntary pledges to binding requirements
These findings suggested that PF augmented the expression levels of EMT biomarkers, which were markedly suppressed by dulaglutide treatment

SK: Conceptualization, Methodology, Software, Formal Analysis, Visualization, Investigation, Writing original draft, Writing review and editing
