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The most frequent side effects observed with retatrutide were mild to moderate and predominantly gastrointestinal in nature

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Finally, the team determined safety and tolerability endpoints, e.g., drug-related adverse events, vitals, laboratory parameters, and electrocardiograms

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As far as CRF1R, CRF2R, AM1R, AM2R and CLR are concerned, their ECL1 are relatively short (consisting of 811 residues) and can only form one-turn -helix to connect the adjacent transmembrane helices TM2 and TM3, contributing limited contacts with the peptides