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Cardiovascular Benefits: In addition to its effects on blood sugar and weight, semaglutide has demonstrated cardiovascular benefits in clinical trials

it is an important part of lowering longterm cardiometabolic risk

The relative frequencies of DKA in individuals taking SGLT2 inhibitors in Japan and in other countries are unknown

The gradual dose titration recommended in prescribing guidance aims to minimise gastrointestinal side effects by allowing the body time to adapt to the medication's effects on gut motility
