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Jump to: Understanding depression and weight | Wegovy and mental health safety | Medication interactions | Foods to focus on | Physical activity | Mental health during weight loss | When to speak to your GP | Frequently asked questions | Take home message You can take Wegovy if you have depression

Unlike older GLP-1 drugs, retatrutides three-way action gives it a more potent effect on both appetite and metabolism, positioning it as useful for obesity treatment

Questions to ask your doctor (if you want to be practical about it) If this headline has you spiraling a bit, bring a short list to your next appointment

Maintaining weight loss requires a long-term commitment to healthy habits and may involve ongoing support from healthcare providers or weight loss programs

Setting realistic expectations is crucial: weight loss is gradual, with clinical trials showing approximately 15% weight reduction with semaglutide 2.4 mg at 68 weeks and up to 21% with tirzepatide at 72 weeks, though individual responses vary considerably