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July 3, 2023

Role of GLP-2 in inflammatory regulation in IBD Administration of teduglutide, a GLP-2 analog to mice with DSS-induced colitis, resulted in a significantly greater small bowel and colon weight and length compared with untreated mice

GLP-1 Mechanism and Its Specific Impact on IBD Pathophysiology GLP-1 agonists work by enhancing insulin secretion, slowing gastric emptying, and activating GLP-1 receptors throughout the GI tract

[DOI] [PMC free article] [PubMed] [Google Scholar] [11].Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ, Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis, The Journal of biological chemistry, 278 (2003) 471478

GLP-1RAs in nervous system In the nervous system, GLP-1 can decrease oxidative stress and inflammatory responses, potentially through reducing the generation of ROS and decreasing the expression of inflammatory cytokines