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Even though excretion in human milk is probably low, renal effects on the offspring cannot be excluded when using SGLT2 inhibitors during lactation, as full functional maturation of the kidney may take 2 years in humans (72)

By mimicking the action of these naturally occurring incretin hormones, tirzepatide helps regulate blood glucose levels, reduces appetite, and slows gastric emptying, leading to improved glycaemic control and weight loss

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Some practices are decimated. Reta also seems to preserve muscle mass better than other GLP-1s

Competing interests Nik Krajnc: has participated in meetings sponsored by, received speaker honoraria or travel funding from BMS/Celgene, Janssen-Cilag, Merck, Novartis, Roche and Sanofi-Genzyme and held a grant for a Multiple Sclerosis Clinical Training Fellowship Programme from the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)