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After all, people with obesity have more muscle mass than people without obesity (because their bodies carry more weight), so it's normal to lose muscle when you lose weight whether by diet, exercise, medications, or surgery

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However, the disparity between mechanistic promise and clinical maturity has direct implications for patient counselling, trial design, regulatory oversight, and ethical considerations surrounding the off-label and grey-market use of these therapies

Amy Sheer Joy -Consultant for PeerView All other authors declare no financial conflicts of interest ### Funding Statement This work was supported by the following grant: NIH/NIDDK R01DK133465 ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained