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doi: 10.1111/dom.12932 24

56 The most common adverse events were gastrointestinal in the preclinical, phase1 and 2 trials similar to trials involving injectable GLP-1 agonists

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Specifically: Monitor routinely muscle strength and function amino-acid profiles short half-life proteins emerging resilience markers (e.g., GDF-15) Mitigate proactively adequate protein intake (1.21.5 g/kg/day) resistance or mixed exercise consider adjuncts that preserve muscle mass identify early biomarker patterns of ERM These steps do not contradict the use of GLP-1RAsthey optimize it

Here are more details about Contrave weight loss results: In the Contrave Obesity Research I (COR-I) study involving more than 1,000 people with obesity, people taking Contrave lost about 6% body weight vs