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Why a 6-Day Half-Life Enables Once-Weekly Dosing With a half-life of 6 days, a meaningful fraction of each dose is still circulating when the next injection is due
Although GLP-1RAs are often thought to be linked to a relatively lower risk of hypoglycemia (13), the combination of GLP-1RAs and other anti-diabetic medications (e.g., sulphonylureas) have shown an elevated risk of hypoglycemia compared to placebo (14)
The assumptions necessary for this computational modeling may not apply well to patients with microvascular dysfunction, significant myocardial scar or prior infarction, or ventricular hypertrophy
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