GLP-1s, Gut Motility & IBS — Noisy Guts
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Description
LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial
It is important because it provides human biomarker-level support for the idea that GLP-1RA therapy influences redox-related physiology in parallel with its metabolic actions
Diabetes 60: 31033109
doi: 10.1056/NEJMoa1901118
Usage is also high among adults with heart disease, at 26%
