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GLP-1 drugs for heart health Trulicity (dulaglutide) was approved in 2020 for individuals with type 2 diabetes, with or without a history of heart disease, to help reduce the risk of serious cardiovascular events, like heart attacks

This has raised red flags around patient safety and market discipline

Up to now the best way to measure insulin in blood consisted of giving both a test dose and a range of standard doses of insulin to mice and then seeing how quickly they developed convulsions from a rise in their blood sugar (hyperglycemia)

Pending the results of the Focus Trial, advocacy for early prophylactic intervention remains a minority opinion, with most opting to continue standard thresholds for treatment

Commonly considered an undesirable off-target for molecular glue degrader programs, GSPT1 is emerging as a promising oncology target