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The standard dose chart recommends staying at 2.5 mg for at least 4 weeks before escalating

16 A subsequent three-month lead-in period was applied before evaluating cancer incidence

However, semaglutide can cause reduced appetite and lower energy initially, so start conservatively and increase intensity gradually

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Obesity is also associated with both increased PsA incidence and reduced therapeutic response to biologic agents (23, 24)
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