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Our studies revealed key signaling mechanisms underlying the role of GPR17 in regulating GLP-1 secretion and suggest future opportunities for pharmacologically targeting GPR17 with inverse agonists to maximize GLP-1 secretion ![Graphical Abstract][1] Graphical Abstract ### Competing Interest Statement The authors have declared no competing interest

The present consensus discusses the role of SUs in contemporary diabetes management in the Gulf Cooperation Council (GCC) countries

It also helps regulate blood sugar and increases insulin secretion, which can boost metabolic health

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This study is based on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare products Regulatory Agency