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There is also an individual patient response

Current Safety Evidence: What Clinical Trials and Real-World Data Tell Us Semaglutide's long-term safety profile comes primarily from the SUSTAIN clinical trial series (up to 2 years) and post-marketing pharmacovigilance

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Doses were titrated upward every 2 weeks to a goal of sitagliptin/metformin 50/1,000 mg twice daily or metformin 1,000 mg twice daily

Quebedeaux, it is important to discuss any medications you are currently taking (including over-the-counter drugs and supplements) in order to make any necessary adjustments and ensure there are no potential interactions