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In addition, miR-33 targets stanniocalcin (intestinal neuroendocrine cell line (STC-1) cells and decreases GCG and CREB1 expression

GLP-1RAs promote glucose uptake in the skeletal muscle by increasing microvascular blood flow and tissue perfusion and inhibit muscle catabolism via the AMP-activated protein kinase pathway [39, 77, 83]

Nat Med 27 , 952953 (2021)

Moreover, while there is substantial evidence supporting the cardioprotective role of GLP-1RA, the data is less conclusive for GIP and GCG, necessitating additional research to clarify their contributions to cardiovascular health

Treatment with GLP-1RAs leads to rapid reduction in blood pressure, which, according to a meta-analysis (266), could substantially lower the risk of cardiovascular disease and mortality
