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Grassi G, Mark A, Esler M

Discoveries of GIP and GLP-1 The first incretin, GIP, was purified from canine intestinal extracts in the late 1960s (8) and initially named gastric inhibitory polypeptide (9) because the peptide inhibited gastrin-stimulated H + secretion (10)

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Peptide medications are susceptible to degradation when exposed to heat, which can reduce their potency and effectiveness

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