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To evaluate the effect of Melatonin administration on mechanical and thermal pain sensitivity in RIFM, the study employed a series of behavioral assessments, such as the von Frey filament test, cold allodynia test, hot plate test, Randall-Sellito test, and tail suspension test, to comprehensively characterize pain responses associated with FM

Weight loss drugs have been available since the 1930s, but their popularity surged recently after the Food and Drug Administration (FDA) approved three GLP-1 receptor agonists for weight loss: Wegovy (semaglutide), Saxenda (liraglutide), and Ozempic (tirzepatide)

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These changes reflect improved metabolic parameters associated with weight loss and improved glycemic control

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