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While we have not tested the full combination in females, we have tested GDF8 and ActA blockade in lean female monkeys 28 and in postmenopausal women in our Phase 1 clinical study in the accompanying manuscript (Gonzalez Trotter et al

The optimal dose depends on the formulation, enhancement strategy used, and research objectives

Overall, the effect of GLP-1RAs on muscle mass shows a high degree of heterogeneity in clinical trials: some studies report that lean body mass reduction accounts for 40% to 60% of total weight loss, while others indicate that the proportion of lean body mass reduction is approximately 15% or lower [50]

Although these initial studies directly manipulate GLP-1R or GLP-1, other ways to influence the GLP-1 pathway are less studied