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The pharmacokinetic steady state where semaglutide serum concentrations plateau is achieved after approximately 45 half-lives, or around 45 weeks, which aligns with when the full appetite-suppressing effect becomes consistent

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Acute Kidney Injury in Patients on SGLT2 Inhibitors: A Propensity-Matched Analysis

[DOI] [PMC free article] [PubMed] 46.Wharton S, Blevins T, Connery L, Rosenstock J, Raha S, Liu R, et al