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Additionally, patients taking multiple glucose-lowering medications, particularly insulin or sulfonylureas in combination with tirzepatide, face substantially elevated hypoglycemia risk and should discuss alcohol consumption very carefully with their healthcare providermany may be advised to abstain entirely

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Protocol: Creatine: 5g daily (no loading) Protein: 1.4-1.6g per kg body weight Resistance training: 3x per week, compound movements, moderate to heavy loads Tracking: Waist circumference, strength logs, monthly progress photos Duration: Continue creatine throughout entire tirzepatide treatment and beyond This protocol maximizes the muscle-sparing effect of creatine while tirzepatide handles the fat loss side