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Injectable weight-loss medications, known as GLP-1s, can be an important tool for losing weightand reducing the risk of a host of health problems.

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GLP-1 receptor agonists cost between $150 and $1,300+ per month depending on formulation, supply, and sourcing

Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit