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Malnutrition risk increases in elderly patients taking tirzepatide due to the combination of age related appetite decline and medication induced appetite suppression

In terms of lowering HbA1c, dulaglutide, when administered once a week, was demonstrated to be more effective than exenatide twice a day, by 1.51% vs.0.99% [94]

The medication may reduce the effectiveness of oral contraceptives, particularly during the first 4 weeks after initiation and following dose escalation, due to delayed gastric emptying