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Semaglutide: Beginning a New Era The first generation of GLP-1 receptor agonists achieved less than 10 percent weight loss on average

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Naturally, when you eat a meal, your intestines release GLP-1

Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]

Additional behaviors generally associated with long-term weight maintenance include regular physical activity (60+ minutes/day)