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GIP receptor activation adds: Enhanced fat metabolism: GIP receptors on adipose tissue promote fat breakdown and reduce fat storage, adding a metabolic dimension to weight loss beyond appetite suppression alone Additive appetite suppression: GIP and GLP-1 receptor activation together produce greater appetite reduction than either pathway alone Improved insulin sensitivity: The combination improves peripheral insulin sensitivity more effectively than GLP-1 activation alone particularly relevant for patients with insulin resistance or type 2 diabetes Tirzepatide is sold under the brand names Mounjaro (diabetes indication) and Zepbound (obesity indication) and is also available as a compounded medication

Collagen stimulation: Heat trauma from the laser jump-starts collagen and elastin remodeling for gradual tightening

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Ultimately, researchers emphasise that GLP-1 agonists are not a standalone cure and must be integrated into a multimodal protocol where conservative treatment, exercise, and diet remain paramount (Faria et al., 2026)

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