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Weight loss induced by lifestyle interventions or GLP-1RAs reduces circulating leptin and increases adiponectin, shifting the immune balance toward greater Treg activity and reduced Th1/Th17 responses [36,37]

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Importantly, these associations persist after accounting for improvements in glycemic control and body weight, suggesting that the observed neuroprotective signal may not be solely attributable to better metabolic management

doi: 10.1111/dom.12390