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Retatrutide is a 39-amino-acid synthetic triple-receptor agonist peptide that activates GLP-1, GIP, and glucagon receptors simultaneously

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Alrededor del ao 1920 se introdujo el trmino incretina que fue el primero en ser usado para definir los factores que regulan la secrecin del pncreas, no obstante, la conexin entre el tracto gastrointestinal y el pncreas solo se propus a finales de la dcada de 1960 cuando la insulina se empez a medir en el plasma

Identified by CAS Number 2381089-83-2, Retatrutide is widely referenced in metabolic and obesity research literature as the first characterized triple agonist targeting the GIP receptor, GLP-1 receptor, and glucagon receptor (GCGR) simultaneously within a single molecular scaffold

Supplemental Table 2, Fig